Faculty and Staff
Faculty/Staff Fitness Program
Nutrition and Exercise Sciences
Emily Ho
Associate Professor, Principal Investigator in the Linus Pauling Institute
Faculty
College of Health and Human Sciences
Oregon State University
117 Milam Hall
Corvallis, OR 97331-5103
| Phone: | 541-737-9559 |
| Fax: | 541-737-6914 |
| E-mail: | Emily.Ho@oregonstate.edu |
Research Interests
Research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies. I am currently interested in understanding the role of the antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. Specifically, I am concerned with the effects of zinc status on DNA damage, DNA repair and stress-response signal pathways. We are also becoming interested in the effects of zinc on the immune system, especially as we age. A large proportion of population does not eat enough zinc, especially the elderly, and hence may be at increased risk for cancer and other disorders. Another major focus in the lab is dietary approaches for prostate cancer prevention. We are investigating the molecular mechanisms by which foods like soy, tea and cruciferous vegetables may protect against prostate cancer.
Publications
Bruno, RS, Song, Y, Leonard, S W,
Mustacich, DJ, Taylor, AW , Traber,
MG, Ho, E (2007) Dietary zinc restriction
in rats alters antioxidant status
and increases plasma F2 isoprostanes.
Journal of Nutritional Biochemistry,
18(8):509-518
Trevisiol, CH, Turner, RT , Pfaff, JE,
Hunter, JC, Menagh, PJ, Hardin, K,
Ho, E, Iwaniec, UT (2007) Impaired
Osteoinduction in a Rat Model
for Chronic Alcohol Abuse. Bone,
41(2):175-180
Additional OSU HHS Author(s): Traber, Maret
Myzak, MC, Tong, P, Dashwood, WM, Dashwood, RH, Ho, E (2007) Sulforaphane retards the growth of human PC-3 prostate cancer xenografts and inhibits HDAC activity in human subjects. Experimental Biology and Medics, 232(2):227-234Additional OSU HHS Author(s): Hardin, Karin Turner, Russell
Dashwood, RH, Myzak, MC, Ho, E (2006) Dietary HDAC inhibitors: Time to rethink weak ligands for cancer prevention. Carcinogenesis, 27(2):344-9
Ho, E. (2006). Dashwood, RH, Myzak, MC and Ho, E. (2006). Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis. 2006 Feb;27(2):344-9.
Myzak, MC, Hardin, K, Dashwood,
RH, Ho, E (2006) Sulforaphane Inhibits
Histone Deacetylase Activity in BPH-1,
LnCaP, and PC-3 Prostate Epithelial
Cells. Carcinogenesis, 27(4):811-819
Myzak, MC, Orner, GA, Ho, E, Dashwood, RH (2006) Sulforaphane suppresses tumorigenesis in Apcmin mice via inhibition of histone deacetylase. The Federation of American Societies for Experimental Biology, 20(3):506-8
Additional OSU HHS Author(s): Hardin, Karin
Myzak, MC, Ho, E, Dashwood, RD (2006) Dietary agents as histone deacetylase inhibitors. Molecular Carcinogenesis, 45(6):443-446
Ermilova, IP, Ermilov, VB, Fischer, KA, Levy, MA, Ho, E, Periera, C, Beckman, JS. (2005). Protection by dietary zinc in the ALS mutant G93A SOD Transgenic Mice. Neuroscience Letters, 379(1):42-6
Offer, T, Ho, E, Bruno, RS, Traber, MG, Kuypers, F, Ames, BN. (2005). A simple assay for frequency of chromosome breaks and loss (Micronuclei) by flow Cytometry of Human Reticulocytes. FASEB Journal, 19(3):485-7
Ohtsu, H, Ho, E, Huang, YS, Chaung, LT, Bray, T. (2005). Conjugated Linoleic Acid Modulates Proliferation and Activation of NFkB and AP1 in Prostate Cancer Cells. Nutrition Research, 25: 655-662
Additional OSU HHS Author(s): Bray, Tammy
Awards and Honors
Ho, E. Phi Kappa Phi Emerging Scholar Award, 2007.
Ho, E. Junior Faculty Award. American Urological Association travel award $1000 to annual conference, 2005.
Research Grants and Contracts
Ho, E, Principal Investigator (2007-
2012) Dietary HDAC inhibitors in
prostate cancer prevention, National
Institutes of Health-National Cancer
Institute. $293,440 direct
Turner, R, Principal Investigator, Iwaniec, U, Lotinun, S, Ho, H, Co-Investigators (2006-2011) Etiology and Treatment of Parathyroid Bone Disease, National Institutes of Health. $188,000
Ho, E, Principal Investigator (2005-2006) Serum carotenoids in insitu and invasive cervical cancer, Northwest Health Foundation. $3,969
Ho, E, Principal Investigator (2006-2007) Dietary inhibitors of histone deacetylase in prostate cancer prevention, Medical Research Foundation and Oregon Health and Science University. $30,000
Ho, E. Gene expression profiling in zinc deficiency. Principal Investigator, College of Health and Human Sciences pilot, $4,900, 2004-2005.
Ho, E. Gene expression profiling with zinc supplementation. Principal Investigator, Oregon State University, General Research Fund, $10,000, 2004-2005.
Ho, E. USDA-NRI-Zinc, gene expression & DNA damage. USDA-NRI grant- $375,000, 2005-2008.
Ho, E. Zinc in prostate cancer. Principal Investigator, Northwest Health Foundation, $22,138, 2004-2006.
Additional OSU HHS Faculty: Turner, Russell
Bray, TM, Ho, E, Co-Investigators (2005-2009) Diet, Endocrine-Immune Interactions & Prostate Cancer, National Institute of Health and National Cancer Institute. $205,000Additional OSU HHS Faculty: Bray, Tammy
Ho, E, Principal Investigator (2005- 2007) Zinc in age-related macular degeneration, Linus Pauling Institute Pilot Grant. $20,000